Women's Health Weekly
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Breast Cancer
Investigators at University of Sherbrooke zero in on breast cancer
January 15th, 2009
According to a study from Sherbrooke, Canada, "Breast cancer is the most common cause of cancer death among women under age 50 years, so it is imperative to identify molecular markers to improve diagnosis and prognosis of this disease. Here, we present a new approach for the identification of breast cancer markers that does not measure gene expression but instead uses the ratio of alternatively spliced mRNAs as its indicator." "Using a high-throughput reverse transcription-PCR-based system for splicing annotation, we monitored the alternative splicing profiles of 600 cancer-associated genes in a panel of 21 normal and 26 cancerous breast tissues. We validated 41...
Source: Women's Health Weekly (2009-01-15)
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