Women's Health Weekly
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Breast Cancer
Data from University of Sao Paulo advance knowledge in breast cancer
January 22nd, 2009
According to a study from Sao Paulo, Brazil, " In animal experiments paclitaxel oleate associated with a cholesterol-rich nanoemulsion concentrated in the neoplastic tissues and showed reduced toxicity and increased antitumor activity compared with paclitaxel-Cremophor EL. Here, a clinical study was performed in breast cancer patients to evaluate the tumoral uptake, pharmacokinetics and toxicity of paclitaxel associated to nanoemulsions." " Twenty-four hours before mastectomy [H-3]paclitaxel oleate associated with [C-14]-cholesteryl oleatenanoemulsion or [H-3]- paclitaxel in Cremophor EL were injected into five patients for collection of blood samples and fragments of...
Source: Women's Health Weekly (2009-01-22)
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