Women's Health Weekly
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Breast Cancer
Research results from E. Capizzi and co-authors update knowledge of breast cancer
January 22nd, 2009
"We tested the reliability of real time reverse transcription polymerase chain reactions as an alternative method for the assessment of ERBB2 status in paraffin-embedded tissues of 83 patients with breast cancer and 20 non-neoplastic controls. PCR was also compared with the immunohistochemical (IHC) HercepTest score and with fluorescence (FISH) and silver (SISH) in-situ hybridization, in 42 selected cases," investigators in Bologna, Italy report. "ERBB2 mRNA was over-expressed in 26/83 (31%) breast cancer samples. using a Cutoff calculated as the mean value of the controls Plus 3 SD or with the receiver operating curve. The PCR test showed a 96% sensitivity and a 100%...
Source: Women's Health Weekly (2009-01-22)
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