Women's Health Weekly
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Breast Cancer
New breast cancer study findings have been reported by scientists at Pennsylvania State University
January 29th, 2009
"Recently the concept that gap junctions play a role in cancer cell metastasis has emerged. However, the mechanism by which this might occur is unknown," researchers in the United States report. "To examine this issue a metastatic breast cancer cell line, MDA-MB-435, was stably transfected with human Cx43 cDNA. Four clones of 435 transfectants (435/Cx43+c1, c6, c8, c14) and two clones of plasmid control (435/hy) were isolated and examined in this study. We found that expressing Cx43 in MDA-MB-435 cells decreased their expression of Cx32 but did not affect gap junctional intercellular communication, migration or invasion through Matrigel. However, forced expression of...
Source: Women's Health Weekly (2009-01-29)
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