Women's Health Weekly
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Breast Cancer
Research from D. Cirillo and co-researchers yields new findings on breast cancer
January 29th, 2009
"The adipocyte-derived peptide leptin acts through binding to specific membrane receptors, of which six isoforms (obRa-f) have been identified up to now. Binding of leptin to its receptor induces activation of different signaling pathways, including the JAK/STAT, MAPK, IRS1, and SOCS3 signaling pathways," scientists writing in the Journal of Cellular Biochemistry report. "Since the circulating levels of leptin are elevated in obese individuals, and excess body weight has been shown to increase breast cancer risk in postmenopausal women, several studies addressed the role of leptin in breast cancer. Expression of leptin and its receptors has been demonstrated to...
Source: Women's Health Weekly (2009-01-29)
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