Women's Health Weekly
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Breast Cancer
Scientists at Indiana University, Medical Department release new data on breast cancer
January 29th, 2009
According to recent research published in the journal Molecular and Cellular Biology, "Estrogen regulates several biological processes through estrogen receptor alpha (ER alpha) and ER beta. ER beta-estrogen signaling is additionally controlled by extracellular signal activated kinases such as AKT." "In this study, we analyzed the effect of AKT on genome-wide ER alpha binding in MCF-7 breast cancer cells. Parental and AKT-overexpressing cells displayed 4,349 and 4,359 ER alpha binding sites, respectively, with similar to 60% overlap. In both cell types, similar to 40% of estrogen-regulated genes associate with ER alpha binding sites; a similar percentage of...
Source: Women's Health Weekly (2009-01-29)
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