Women's Health Weekly
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Breast Cancer
Studies from I. Wolf et al provide new data on breast cancer
January 29th, 2009
According to a study from Ramat Gan, Israel, "Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes. As IGF-1 and insulin regulate proliferation, survival and metastasis of breast cancer, we studied klotho expression and activities in human breast cancer." "Immunohistochemistry analysis of klotho expression in breast tissue arrays revealed high klotho expression in normal breast samples, but very low expression in breast cancer. In cancer samples, high klotho expression was associated with smaller tumor size and reduced KI67 staining. Forced expression of klotho...
Source: Women's Health Weekly (2009-01-29)
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