Women's Health Weekly
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Cancer
New cancer study findings reported from National Cancer Institute
January 29th, 2009
"Germ-line mutations in BRCA2 have been linked to early-onset familial breast cancer. BRCA2 is known to play a key role in repairing double-strand breaks," investigators in the United States report. "Here, we describe the involvement of BRCA2 in O-6-alkylguanine DNA alkyltransferase (AGT)-mediated repair of O-6-methylguanine adducts. We show that BRCA2 physically associates and undergoes repair-mediated degradation with AGT. In contrast, BRCA2 with a 29-amino-acid deletion in an evolutionarily conserved domain does not bind to alkylated AGT; the two proteins are not degraded; and mouse embryonic fibroblasts are specifically sensitive to alkylating agents that result in...
Source: Women's Health Weekly (2009-01-29)
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