Women's Health Weekly
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Carcinoma
Research on carcinoma published by A. Tomassetti et al
January 29th, 2009
According to recent research published in the journal Neoplasia, "Ovarian carcinoma arises from the ovarian surface epithelium, which undergoes phenotypic changes characteristic of mullerian epithelium during the first stages of tumorigenesis. The variant isoform of the hepatocyte nuclear factor 1 (vHNF1) is a transcription factor involved in the development of tissues derived from the mullerian duct." "Here, we show that vHNF1 knockdown in two ovarian carcinoma cell lines, SKOV3 and IGROV1, leads to reduced E-cadherin (E-cadh) expression and decreased proliferation rate. Accordingly, SKOV3 cells ectopically expressing a dominant-negative (DN) vHNF1 mutant...
Source: Women's Health Weekly (2009-01-29)
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