Women's Health Weekly
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Breast Cancer
Research from University College in breast cancer provides new insights
February 5th, 2009
According to recent research from Dublin, Ireland, "Aberrant glycosylation on glycoproteins that are either presented on the surface or secreted by cancer cells is a potential source of disease biomarkers and provides insights into disease pathogenesis. N-Glycans of the total serum glycoproteins from advanced breast cancer patients and healthy individuals were sequenced by HPLC with fluorescence detection coupled with exoglycosidase digestions and mass spectrometry." "We observed a significant increase in a trisialylated triantennary glycan containing alpha 1,3-linked fucose which forms part of the sialyl Lewis x epitope. Following digestion of the total glycan pool...
Source: Women's Health Weekly (2009-02-05)
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