Women's Health Weekly
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Cancer
Reports outline cancer research from University of California
February 5th, 2009
"Quinoxolinehydrazines represent a novel class of compounds with excellent potency in a panel of cancer cell lines. A prototype compound, SC144, showed significant in vivo efficacy in mice xenogroft models of human breast cancer cells," researchers in the United States report. "The subsequent structure-activity relationship study resulted in the discovery of SC161 with better potency in cancer cell lines. Further exploring the possible conformational space by a 10 ns molecular dynamics simulation as presented herein, resulted in various pharmacophore orientations. The trajectory analysis indicated that in most of the simulation time, the molecule stays favorably in a...
Source: Women's Health Weekly (2009-02-05)
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