Women's Health Weekly
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Cancer
Studies from Queen's University have provided new data on cancer
February 5th, 2009
"Osteopontin (OPN) is a phosphorylated glycoprotein that binds to alpha v-containing integrins and is important in malignant transformation and cancer. Previously, we have utilized suppressive subtractive hybridization between mRNAs isolated from the Rama 37 (R37) rat mammary cell line and a subclone rendered invasive and metastatic by stable transfection with an expression vector for OPN to identify RAN GTPase (RAN) as the most over-expressed gene, in addition to that of OPN," researchers in North Ireland report. "Here we show that transfection of noninvasive R37 cells with an expression vector for RAN resulted in increased anchorage-independent growth, cell attachment...
Source: Women's Health Weekly (2009-02-05)
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