Women's Health Weekly
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Breast Cancer
Data on breast cancer discussed by B. Chen and colleagues
February 5th, 2009
According to a study from the United States, "ERBB2 overexpression in estrogen receptor (ER)-positive breast cancer cells such as BT474 (BT) cells has been found to confer resistance to tamoxifen, and suppression of ERBB2 improves the antiproliferative effects of tamoxifen. In this study, the responsiveness to tamoxifen in the BT/HerR, Herceptin-resistant BT cell lines established through constant Herceptin exposure, was evaluated." "Compared with BT cells, improvement of sensitivity to tamoxifen in BT/HerR was demonstrated by ER functional analysis and cell proliferation assay. Tamoxifen in the resistant cell line was found to inhibit 17 beta-estradiol-stimulating...
Source: Women's Health Weekly (2009-02-05)
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