Women's Health Weekly
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Breast Cancer
Data on breast cancer discussed by D. Generali and colleagues
February 26th, 2009
According to a study from Melbourne, Australia, " We aimed to identify signaling pathways involved in the response and resistance to aromatase inhibitor therapy in patients with breast cancer. Patients and Methods One hundred fourteen women with T2-4 N0-1, estrogen receptor (ER) alpha-positive tumors were randomly assigned to neoadjuvant letrozole or letrozole plus metronomic cyclophosphamide." "Twenty-four tumor proteins involved in apoptosis, cell survival, hypoxia, angiogenesis, growth factor, and hormone signaling were assessed by immunohistochemistry in pretreatment samples (eg, caspase 3, phospho-mammalian target of rapamycin, hypoxia-inducible factor 1 alpha...
Source: Women's Health Weekly (2009-02-26)
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