Women's Health Weekly
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Breast Cancer
Research conducted at University of Gottingen has updated our knowledge about breast cancer
February 26th, 2009
"Mammary oncogenesis is profoundly influenced by signaling pathways controlled by estrogen receptor alpha (ER alpha). Although it is known that ER alpha exerts its oncogenic effect by stimulating the proliferation of many human breast cancers through the activation of target genes, our knowledge of the underlying transcriptional mechanisms remains limited," investigators in Germany report. "Our published work has shown that the in vivo activity of LIM homeodomain transcription factors (LIM-HD) is critically regulated by cofactors of LIM-HD proteins (CLIM) and the ubiquitin ligase RING finger LIM domain-interacting protein (RLIM). Here, we identify CLIM and RLIM as novel...
Source: Women's Health Weekly (2009-02-26)
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