Women's Health Weekly
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Breast Cancer
Research from University of Texas has provided new information about breast cancer
February 26th, 2009
"Ribosomal protein S6 kinase 1 (S6K1), a critical mediator of cell growth, is overexpressed in breast cancer and is associated with poor prognosis. S6K1 has two known isoforms, p85(S6K1) and p70(S6K1). p85S6K1 is characterized by 23 additional amino acids in the N-terminus of p70S6K1," scientists writing in the journal Growth Factors report. "This is thought to target p85(S6K1) to the nucleus, while p70(S6K1) is mainly cytoplasmic. We sought to determine the activation, regulation, and function of p70(S6K1) and p85(S6K1) in breast cancer. We found that most breast cancer cell lines expressed both isoforms. Mitogen-dependent pathways concordantly regulated...
Source: Women's Health Weekly (2009-02-26)
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