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Women's Health Weekly

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Breast Cancer



Research on breast cancer discussed by scientists at Matsumoto Dental University



February 26th, 2009

According to recent research published in the Journal of Bone and Mineral Metabolism, "Osteoclasts are formed from the monocyte-macrophage lineage in response to receptor activator of nuclear factor kappa B ligand (RANKL) expressed by osteoblasts. Bone is the most common site of breast cancer metastasis, and osteoclasts play roles in the metastasis."

"The taxane-derived compounds paclitaxel and docetaxel are used for the treatment of malignant diseases, including breast cancer. Here we explored the effects of docetaxel on osteoclastic bone resorption in mouse culture systems. Osteoclasts were formed within 6 days in cocultures of osteoblasts and bone marrow cells...


Source: Women's Health Weekly (2009-02-26)

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