Women's Health Weekly
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Breast Cancer
Researchers from University of Queensland discuss findings in breast cancer
February 26th, 2009
"Nuclear factor-kappa B pathway (NF-kappa B) is activated in many breast cancers. NF-(DB)-B-o has interactions with other pathways such as the nerve growth factor (NGF) pathway, which is involved in the survival and proliferation of breast cancer cells," scientists writing in the Journal of Cancer Research and Clinical Oncology report. "NGF treatment of breast cancer cells activates NF-kappa B resulting in the inhibition of ceramide-induced apoptosis. NGF effects on apoptosis and cell proliferation are mediated through p75NTR and p140TrkA receptors, respectively. In this study we investigate the NGF/NF-kappa B pathway as a therapeutic target in breast cancer. We...
Source: Women's Health Weekly (2009-02-26)
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