Women's Health Weekly
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Breast Cancer
Studies from S. Badve and co-authors have provided new information about breast cancer
February 26th, 2009
According to a study from the United States, "The oestrogen receptor (ER) pathway is key for survival and progression in a significant proportion of breast cancers. The ER can be activated by oestrogen or activated due to ''crosstalk'' with growth factor receptor pathways." "Activated ER signals through transcriptional and non-transcriptional mechanisms. Immunohistochemistry (IHC), in spite of the shortcomings, remains the method of choice as it provides for in situ assessment of ER expression within the tumour cells. This capability is lost in tissue grinding methods that assess oestrogen-binding activity or messenger RNAs in tumours. IHC is also not influenced by the...
Source: Women's Health Weekly (2009-02-26)
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