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Massachusetts General Hospital

International study identifies gene variants associated with early heart attack

Published in Women's Health Weekly, February 26th, 2009

The largest study ever completed of genetic factors associated with heart attacks has identified nine genetic regions – three not previously described – that appear to increase the risk for early-onset myocardial infarction. The report from the Myocardial Infarction Genetics Consortium, based on information from a total of 26,000 inviduals in 10 countries, will appear in Nature Genetics and is receiving early online release.

"For several decades, it has been known that the risk for heart attack – the leading cause of death and disability in the U.S. – clusters in families and that some of this familial clustering is due to differences in DNA sequence," says Sekar...

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