Cancer

Research conducted at Vanderbilt University has provided new information about cancer

Published in Women's Health Weekly, March 5th, 2009

According to a study from the United States, "Tyrosine kinase inhibitors (TKIs) are effective anti-cancer therapies but resistance to these agents eventually develops. Several models of resistance to TKIs have been studied including resistance to EGFR inhibitors."

"Recent studies in EGFR-dependent A431 cells found upregulation of the IGF1R pathway as a mechanism to overcome blockade of EGFR. This was associated with amplification of IGF1R signaling and recovery of downstream PI3K-AKT activation. This work adds to a growing body of cell lines in culture that have provided insights into mechanisms of resistance that can be interrogated in primary tumors in patients,"...

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Source: Women's Health Weekly (2009-03-05)

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