Women's Health Weekly
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Breast Cancer
Findings from University of California broaden understanding of breast cancer
March 5th, 2009
"Four ''one-bead one-compound'' (OBOC combinatorial libraries were designed, synthesized, and screened against MDA-MB-231 breast cancer cells. A novel cyclic peptide 1 (LXY1) with high binding specificity C) C to 0 integrin was identified," scientists in the United States report. "Molecular interactions between 0 integrin and I were characterized by using a series of K562 cells transfected with various mutant alpha 3 integrins. Using analytic flow cytometry, the binding affinity (K-d) of 1 to alpha 3 integrin on MDA-MB-231 breast cancer cells was determined to be approximately 0.4 mc M. Based on the established structure-activity relationship (SAR) study, two highly...
Source: Women's Health Weekly (2009-03-05)
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