Women's Health Weekly
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Breast Cancer
Findings in breast cancer reported from Radboud University
March 5th, 2009
According to recent research published in the journal Biochemical and Biophysical Research Communications, "EFbB3 transactivation can make tumor cells resistance to ErbB1/ErbB2 targeting drugs." "This Urges for a reliable method to determine cell surface ErbB3 levels, but ill our hands iodinated NRG1 beta is unstable and tends to Underestimate the number of ErhB3 receptors in a radio-receptor assay. Here we show by the use of a radio-labeled high affinity neuregulin Mutant NRG/YYDLL that ErbB3 levels can be determined in a reliable manner by Scatchard analysis," wrote S.P. Vanderwoning and colleagues, Radboud University. The researchers...
Source: Women's Health Weekly (2009-03-05)
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