Human Papillomavirus

Study findings from National Institutes of Health provide new insights into human papillomavirus

Published in Women's Health Weekly, March 5th, 2009

According to a study from the United States, "For many papillomaviruses, the viral protein E2 tethers the viral genome to the host mitotic chromosomes to ensure persistent, long-term maintenance of the genome during cell division. Our previous studies of E2 proteins from different genera of papillomaviruses have shown that they bind to different regions of the host chromosomes during mitosis."

"For example, bovine papillomavirus type 1 (BPV-1) E2 binds to all chromosomes as small speckles in complex with the cellular protein Brd4. In contrast, the human papillomavirus type 8 (HPV-8) E2 protein binds as large speckles at the pericentromeric regions of chromosomes. Here...

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Source: Women's Health Weekly (2009-03-05)

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