Women's Health Weekly
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Breast Cancer
Research data from M. Kok and colleagues update understanding of breast cancer
March 5th, 2009
" Molecular signatures that predict outcome in tamoxifen treated breast cancer patients have been identified. For the first time, we compared these response profiles in an independent cohort of (neo)adjuvant systemic treatment na < ve breast cancer patients treated with first-line tamoxifen for metastatic disease," scientists writing in the journal Breast Cancer Research and Treatment report. " From a consecutive series of 246 estrogen receptor (ER) positive primary tumors, gene expression profiling was performed on available frozen tumors using 44K oligoarrays (n = 69). A 78-gene tamoxifen response profile (formerly consisting of 81 cDNA-clones), a 21-gene...
Source: Women's Health Weekly (2009-03-05)
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