Women's Health Weekly
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Breast Cancer
Research in the area of breast cancer reported from A. Osorio and colleagues
March 5th, 2009
"RAP80 and CCDC98 have arisen as new candidate breast cancer susceptibility genes, since they encode for two very recently identified BRCA1 interacting proteins," scientists writing in the journal Breast Cancer Research and Treatment report. "In this study we have performed the first mutational analysis of both genes in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2. We have not found truncating mutations in any of the genes and only two missense variants, p.Tyr564His in RAP80, and p.Met299Ile in CCDC98 were found that could be suspected to have a pathogenic effect, although further analyses suggested that they were...
Source: Women's Health Weekly (2009-03-05)
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