Women's Health Weekly
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Breast Cancer
Researchers' work from University of Pittsburgh focuses on breast cancer
March 12th, 2009
According to a study from the United States, "Leptin, a 16 kDa polypeptide hormone, implicated in various physiological processes, exerts its action through the leptin receptor, a member of the class I cytokine receptor family. Both leptin and leptin receptor have recently been implicated in processes leading to breast cancer initiation and progression in animal models and humans." "An A to G transition mutation in codon 223 in exon 6 of the leptin receptor gene, resulting in glutamine to arginine substitution (Gln223Arg), lies within the first of two putative leptin-binding regions and may be associated with impaired signaling capacity of the leptin receptor. This...
Source: Women's Health Weekly (2009-03-12)
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