Women's Health Weekly
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Cancer
Data on cancer detailed by D.S. Kim and co-authors
March 12th, 2009
According to a study from South Korea, "The cross-linking enzyme, Transglutaminase 2 (TGase 2), contributes to physiological homeostasis and plays a role in cell death and survival. We previously showed that down-regulation of TGase 2 by cystamine or synthetic peptide R2 promotes apoptosis in drug-resistant cancer cells by restoring the level of I-kappa B kappa, leading to inactivation of NF-kappa B. To better define the action of TGase 2, its expression was blocked by small interfering RNA." "This interference rendered, the doxorubicin-resistant breast cancer cells, highly susceptible to doxorubicin-induced apoptosis. This susceptibility, was associated with decreased...
Source: Women's Health Weekly (2009-03-12)
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