Women's Health Weekly
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Breast Cancer
Researchers' work from Erasmus University focuses on breast cancer
March 19th, 2009
According to recent research from Netherlands, " We have previously identified a set of breast cancer antiestrogen resistance (BCAR) genes causing estrogen independence and tamoxifen resistance in vitro using a functional genetic screen. Here, we explored whether these BCAR genes provide predictive value for tamoxifen resistance and prognostic information for tumor aggressiveness in breast cancer patients." "Patients and Methods mRNA levels of 10 BCAR genes (AKT1, AKT2, BCAR1, BCAR3, EGFR, ERBB2, GRB7, SRC, TLE3, and TRERF1) were measured in estrogen receptor-positive breast tumors using quantitative reverse- transcriptase polymerase chain reaction. Normalized mRNA...
Source: Women's Health Weekly (2009-03-19)
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