Women's Health Weekly
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Breast Cancer
Kaohsiung Medical University reports research in breast cancer
March 26th, 2009
According to a study from Kaohsiung, Taiwan, "Withanolides are C-28 steroidal lactones isolated from plants that exhibit potent anti-cancer activity. The chemokine receptor CCR7 is important for lymphatic invasion of cancer cells and is overexpressed in metastatic breast cancer cells." "A bioactive withanolide tubocapsanolide A (Tubo A) suppressed NF-kappa B-mediated CCR7 expression in breast cancer cells and attenuated their migration toward lymphatic endothelial cells. Chromatin immunoprecipitation assay confirmed that binding of NF-kappa B to the consensus site localized at the -398/-389 of human CCR7 promoter was repressed by Tubo A. Tubo A inhibited I kappa B...
Source: Women's Health Weekly (2009-03-26)
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