Women's Health Weekly
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Breast Cancer
New breast cancer findings from GlaxoSmithKline published
March 26th, 2009
According to recent research from the United States, "Lapatinib is a tyrosine kinase inhibitor approved for use in combination with capecitabine to treat advanced or metastatic breast cancers overexpressing human epidermal receptor 2 (ErbB2). This work investigated the role of P-glycoprotein (Pgp; the protein from the Mdr1a/b gene) and breast cancer resistance protein (Bcrp; the protein from the Bcrp1 gene) in modulating the central nervous system penetration of lapatinib at steady-state conditions in FVBn mice (wild-type), Mdr1a/b(-/-), Bcrp1(-/-), and Mdr1a/b(-/-)/Bcrp1(-/-) knockout mice." "After an intravenous infusion of lapatinib for 24 h to a targeted...
Source: Women's Health Weekly (2009-03-26)
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