Women's Health Weekly
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Breast Cancer
Research data from CRC Beatson Labs update understanding of breast cancer
March 26th, 2009
According to a study from Scotland, "Early clinical trials of anticancer agents may be enriched by robust biomarkers of activity. Surrogate measures used in trials of cytotoxic agents, such as tumor size regression, may not be informative when investigating targeted agents that act principally to inhibit invasion or proliferation." "This study aimed to determine the validity of invasion-related biomarkers of activity for AZD0530, a potent Src inhibitor currently in clinical development. Focal adhesion kinase (FAK) and paxillin are downstream phosphorylation substrates of Src and mediate tumor cell adhesion and invasiveness. These were therefore selected as biologically...
Source: Women's Health Weekly (2009-03-26)
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