Women's Health Weekly
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Breast Cancer
Research from D. Generali et al has provided new information about breast cancer
March 26th, 2009
"We have shown previously that tumor infiltration by FOXP3(+) regulatory T cells (Treg) is associated with increased relapse and shorter survival of patients with both in situ and invasive breast cancer. Because estrogen regulates Treg numbers in mice and promotes the proliferation of human Tregs, we hypothesized that blocking estrogen receptor-alpha signaling would abrogate Tregs and be associated with response to hormonal therapy and increased survival," investigators in Melbourne, Australia report. "FOXP3(+) Tregs were quantified in tumor samples collected at baseline by incisional biopsy and after 6 months at definitive surgery in 83 elderly breast cancer patients...
Source: Women's Health Weekly (2009-03-26)
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