Women's Health Weekly
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Breast Cancer
Research on breast cancer reported by M. Lae et al
March 26th, 2009
According to a study from Paris, France, "Secretory breast carcinomas (< 0.15% of breast tumors) are associated with a characteristic morphology and a favorable prognosis. Remarkably, this entity is the only epithelial tumor of the breast with a balanced translocation, t(12; 15), that creates an ETV6-NTRK3 gene fusion encoding chimeric tyrosine kinase also encountered in cellular mesoblastic nephroma and infantile fibrosarcoma." "The aim of this study was to determine the phenotypic class (ie luminal A/B, ERBB2, basal-like) of secretory breast carcinoma. A series of six secretory breast carcinomas were identified in our files. The ETV6 rearrangement was confirmed in...
Source: Women's Health Weekly (2009-03-26)
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