Women's Health Weekly
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Breast Cancer
Findings from New York University, Medical Department provide new insights into breast cancer
April 2nd, 2009
According to a study from the United States, "Expression of the nuclear receptor interacting factor 3 (NRIF3) coregulator in a wide variety of breast cancer cells selectively leads to rapid caspase-2-dependent apoptotic cell death. A novel death domain (DDI) was mapped to a 30-amino acid region of NRIF3." "Because the cytotoxicity of NRIF3 and DDI seems to be cell type-specific, these studies suggest that breast cancer cells contain a novel ''death switch'' that can be specifically modulated by NRIF3 or DID I. Using an MCF-7 cell cDNA library in a yeast two-hybrid screen, we cloned a factor that mediates apoptosis by DDI and refer to this factor as DDI-interacting...
Source: Women's Health Weekly (2009-04-02)
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