Women's Health Weekly
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Breast Cancer
Investigators at University of Alabama target breast cancer
April 2nd, 2009
"Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to suppression of metastasis without blocking orthotopic tumor growth in multiple human and murine cancer cells of diverse origins. We hypothesized that miR-146 may be involved in the ability of BRMS1 to supress metastasis because miR-146 expression is altered by BRMS1 and because BRMS1 and miR-146 are both associated,with decreased signaling through the nuclear factor-kappa B pathway," scientists writing in the journal Cancer Research report. "BRMS1 significantly up-regulates miR-146a by 6- to 60-fold in metastatic...
Source: Women's Health Weekly (2009-04-02)
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