Women's Health Weekly
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Breast Cancer
New breast cancer study results reported from University of Maryland, Medical Department
April 2nd, 2009
"In this study, we investigated adaptive mechanisms associated with aromatase inhibitor (AI) resistance in breast cancer cells and show that sensitivity to AIs can be extended through dual inhibition of estrogen receptor (ER) and human epidermal receptor-2 (Her-2) signaling. We used human ER-positive breast cancer cells stably transfected with the aromatase gene (MCF-7Ca)," scientists writing in the journal Cancer Research report. "These cells grow as tumors in nude mice and are inhibited by AIs. Despite continued treatment, tumors eventually become insensitive to AI letrozole. The cells isolated from these long-term letrozole-treated tumors (LTLT-Ca) were found...
Source: Women's Health Weekly (2009-04-02)
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