Women's Health Weekly
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Breast Cancer
New findings from INSERM in the area of breast cancer described
April 2nd, 2009
"Taxol is widely used in breast cancer chemotherapy. Its effects are primarily attributed to its anti-mitotic activity," investigators in Tours, France report. "Microtubule perturbators also exert antimetastatic activities which cannot be explained solely by the inhibition of proliferation. Voltage-dependent sodium channels (Na-v) are abnormally expressed in the highly metastatic breast cancer cell line MDA-MB-231 and not in MDA-MB-468 cell line. Inhibiting Nav activity with tetroclotoxin is responsible for an approximately 0.4-fold reduction of MDA-MB-231 cell invasiveness. In this Study, we focused on the effect of a single, 2-h application of 10 nM taxol on the two...
Source: Women's Health Weekly (2009-04-02)
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