Women's Health Weekly
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Breast Cancer
Reports outline breast cancer study results from University of Wisconsin
April 2nd, 2009
According to recent research published in the journal Molecular Endocrinology, "Despite the growing body of evidence supporting prolactin (PRL) actions in human breast cancer, little is known regarding PRL regulation of its own receptor in these cells. Ligand-initiated endocytosis is a key process in the regulation of receptor availability and signaling cascades that may lead to oncogenic actions." "Although exposure to exogenous PRL accelerates degradation of the long isoform of the PRL receptor (IPRLR), neither the signals initiated by PRL that lead to IPRLR internalization and subsequent down-regulation, nor the relationship to downstream pathways are...
Source: Women's Health Weekly (2009-04-02)
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