Women's Health Weekly
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Drug Resistance
New drug resistance study findings reported from Medical University of South Carolina
April 2nd, 2009
"Interactions of hyaluronan with CD44 in tumor cells play important cooperative roles in various aspects of malignancy and drug resistance. Emmprin (CD147; basigin) is a cell surface glycoprotein of the immunoglobulin superfamily that is highly up-regulated in malignant cancer cells and stimulates hyaluronan production, as well as several downstream signaling pathways," scientists writing in the journal Cancer Research report. "Emmprin also interacts with various monocarboxylate transporters (MCT). Malignant cancer cells use the glycolytic pathway anti require MCTs to efflux lactate that results from glycolysis. Glycolysis and lactate secretion contribute to...
Source: Women's Health Weekly (2009-04-02)
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