Women's Health Weekly
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Drug Resistance
Scientists at University of Missouri release new data on drug resistance
April 2nd, 2009
According to a study from the United States, "Breast Cancer Resistance Protein (BCRP) belongs to the family of efflux transporters involved in drug efflux leading to drug resistance. The objective of this study was to explore physical barriers for ocular drug absorption and to verify the presence and possible role of BCRP as a barrier for ocular drug resistance." "Transfected human corneal epithelial cells (SV40-HCEC) wereselectedas an in vitro model for corneal epithelium with MDCKII-BCRP as positive control. [3H]-Mitoxantrone ([3H]-MTX), which is a proven substrate for organic anion transporter like BCRP, was selected as a model drug for functional expression studies....
Source: Women's Health Weekly (2009-04-02)
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