Women's Health Weekly
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Breast Cancer
Data on breast cancer reported by J.D. Graham and co-researchers
April 2nd, 2009
According to a study from Westmead, Australia, "The ovarian hormone progesterone is essential for normal breast development, and progesterone analogues are implicated in increasing breast cancer risk. The progesterone receptor (PR) is a transcription factor that, when ligand activated, moves rapidly into nuclear foci associated with transcriptional activity." "However, the role of intranuclear trafficking signals in the focal location of PR is unknown. We have identified a mutation in PR that ablates its binding to the nuclear matrix and prevents PR movement into nuclear foci. Nuclear matrix binding mutants lack transcriptional activity and inhibit dimerization,...
Source: Women's Health Weekly (2009-04-02)
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