Women's Health Weekly
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Carcinoma
New carcinoma study findings have been reported by C. Saldana and co-researchers
April 9th, 2009
"Breast carcinoma-derived MCF-7 cells are frequently used in biomedical research. However, few reports exist regarding the characterization of signaling mechanisms in these cancerous cells involved in intracellular Ca2+ dynamics," scientists writing in the journal Molecular and Cellular Biochemistry report. "Consequently, the aim of these experiments was to characterize the ryanodine receptor/Ca2+ release channel (RyR) present in MCF-7 cells. Ryanodine (100 nM), cADPR (5 mc M), and caffeine (10 mM) promoted cytoplasmic Ca2+ mobilization; in contrast, ryanodine at inhibitory concentration (100 mc M) decreased the basal Ca2+ level. Fluorescent probes demonstrated...
Source: Women's Health Weekly (2009-04-09)
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