Women's Health Weekly
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Carcinoma
Research on carcinoma described by N. Kapuriya and colleagues
April 9th, 2009
According to recent research published in the journal Bioorganic & Medicinal Chemistry, "A series of phenyl N-mustard-9-anilinoacridine conjugates via a carbamate or carbonate linker was synthesized for antitumor evaluation. The carbamate or carbonate linker is able to lower the reactivity of the phenyl N-mustard pharmacophore and thus, these conjugates are rather chemically stable." "The in vitro studies revealed that these derivatives possessed significant cytotoxicity with IC50 in sub-micromolar range in inhibiting human lymphoblastic leukemia (CCRF-CEM), breast carcinoma (MX-1), colon carcinoma (HCT-116) and human non-small cell lung cancer (H1299) cell...
Source: Women's Health Weekly (2009-04-09)
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