Women's Health Weekly
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Breast Cancer
Findings from Baylor University provide new insights into breast cancer
April 16th, 2009
According to a study from the United States, "CD40 ligand (CD40L, CD154) plays a central role in immunoregulation and also directly modulates epithelial cell growth and differentiation. We previously showed that the CD40 receptor is commonly expressed in primary breast cancer tissues." "In this proof-of-principle study, we examined the breast cancer growth-regulatory activities of an oncolytic adenoviral construct carrying the CD40L transgene (AdEHCD40L). In vitro and in vivo evaluations were carried out on AdEHCD40L to validate selective viral replication and CD40L transgene activity in hypoxia inducing factor-1 alpha and estrogen receptor-expressing human breast...
Source: Women's Health Weekly (2009-04-16)
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