Women's Health Weekly
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Breast Cancer
Research by D. Lopez and colleagues in breast cancer provides new insights
April 23rd, 2009
According to a study from the United States, "Endothelial integrity is dependent on intracellular adherens junctions formed by Complexes Of vascular endothelial (VE)-cadherin and catenins. We have previously demonstrated that exposing endothelial cells (EC) to breast cancer cell-conditioned media (CM) for 24 h results in a reduction in VE-cadherin protein and rnRNA levels." "Herein, we examined the mechanism(s) involved in the downregulation of VE-cadherin by CM. Human dermal microvascular EC exposed to CM showed a downregulation in VE-cadherin promoter activity and upregulation of Twist, Sing, and Snail expression. Reporter gene analysis demonstrated a direct...
Source: Women's Health Weekly (2009-04-23)
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