Women's Health Weekly
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Cancer
Study results from University of Queensland in the area of cancer published
April 23rd, 2009
"Herein we report a method for the detection of methylated CpG dinucleotides located within CpG islands in genomic DNA using multiplexed bead-based assays and standard flow cytometry instrumentation. Four CpG ''clusters'' were identified in the TFPI2 and SPARC CpG islands whose methylation status was highly correlated with the incidence of invasive cervical cancer in our previous studies," investigators in Australia report. "Eight probes in total were designed for both the methylated and unmethylated forms of each cluster and attached to different fluorescently-encoded organosilica bead sets. Probe design was investigated by changing either the length of probes whilst...
Source: Women's Health Weekly (2009-04-23)
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