Women's Health Weekly
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Cervical Cancer
New cervical cancer findings from China Three Gorges University published
April 23rd, 2009
According to recent research from Yichang, People's Republic of China, " The tumor suppressor adenomatous polyposis coli (APC) is frequently silenced by promoter hypermethylation in human cervical cancer. Clinically, it has been approved that DNA methylation inhibitors, such as 5-aza-2'-deoxycytidine (5-Aza-dC), can reverse APC promoter methylation, but widespread clinical use of these inhibitors is limited by their toxicity and instability in aqueous solution." "Hydralazine is a stable DNA methylation inhibitor that has minimal toxicity in vitro and in vivo. The purpose of this study was to evaluate the effects of hydralazine on APC reactivation and the inhibition of...
Source: Women's Health Weekly (2009-04-23)
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