Women's Health Weekly
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Breast Cancer
New findings from State University of New York in the area of breast cancer described
April 30th, 2009
"Aberrant promoter methylation is recognized as an important feature of breast carcinogenesis. We hypothesized that genetic variation of genes for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR), two critical enzymes in the one-carbon metabolism, may alter DNA methylation levels and thus influence DNA methylation in breast cancer," scientists in the United States report. "We evaluated case-control association of MTHFR C677T, A1298C, and MTR A2756G polymorphisms for cases strata-defined by promoter methylation status for each of three genes, E-cadherin, p16, and RAR-beta(2) in breast cancer; in addition, we evaluated case-case comparisons of the...
Source: Women's Health Weekly (2009-04-30)
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