Women's Health Weekly
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Breast Cancer
Research data from Duke University update understanding of breast cancer
April 30th, 2009
"Only 5% of all breast cancers are the result of BRCA1/2 mutations. Methylation silencing of tumor suppressor genes is well described in sporadic breast cancer; however, its role in familial breast cancer is not known," scientists in the United States report. "CpG island promoter methylation was tested in the initial random periareolar fine-needle aspiration sample from 109 asymptomatic women at high risk for breast cancer. Promoter methylation targets included RARB (M3 and M4), ESR1, INK4a/ARF BRCA1, PRA, PRB, RASSF1A, HIN-1, and CRBP1. Although the overall frequency of CpG island promoter methylation events increased with age (P < 0.0001), no specific methylation...
Source: Women's Health Weekly (2009-04-30)
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